With A Single Blood Drop, This Test Rapidly Recognizes Signs of Sepsis – ZMR Blog
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With A Single Blood Drop, This Test Rapidly Recognizes Signs of Sepsis

With A Single Blood Drop, This Test Rapidly Recognizes Signs of Sepsis

As it is known, an infection in the body can stimulate sepsis. In response, the immune system liberates chemicals that combat the infection; however, it can also result in widespread inflammation that can quicklyresult in organ failure and ultimately, death. A hope is given by a research team at the Carle Foundation Hospital in Urbana and the University of Illinois as they accomplishthe clinical trial of the device, which canofferfast, point-of-care measurement of the response of theimmune system, without the need for blood processing.

According to the team, this can assist doctors to detect sepsis at its initial stage, observe infected patients, and can even point to a diagnosis. Normally, sepsis is identified by observing the vital signs of a patient, including temperature,oxygen levels, blood pressure, and others. If a patient exhibits symptoms of being septic, the professionalsattempt to verify the infectionsource with blood cultures and other assays that are time-consuming. However, the new device uses a distinct approach.

Rashid Bashir, Team Leader, said, “We are seeking the immune reaction, instead of focusing on recognizing the infection source. The immune system of one individual may react distinctly from the other individual to thesame infection. This test can match the bacterial identification and detection. We believe we require both approaches: identify the pathogen, but also observe the immune response.”

blood drop

The tiny, lab-on-a-chip device measures the totalwhite blood cells as well as particular white blood cells known asneutrophils and estimates a protein marker known as CD64 on the neutrophils’ surface. The CD64 levelsrise as the immune response of the patientincreases.

The device was validatedby the team with blood samples from Carle patients in the emergency room and ICU. When a physician presumed infection and recommended a blood test, a tiny blood drop was drawn and given to the research team, without theircognizingdata to protect patient confidentiality. The researchers were able to observe the levels of CD64 over time, associating them with the vital signs of the patient. The team found that the outcomes from the rapid test associated well with the outcomes from the traditional assays and with thevital signs of the patients.

At present, Bashir’s team is functioning to integrateestimations for other inflammation markers into the fast-testing device to offer a more comprehensiverepresentation of the response by the body, and to facilitate earlier recognition. They also possess a startup firm, Prenosis Inc., which is operational to commercialize the device.

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