Damage caused by Parkinson’s disease can be estimated via Waterlogged Brain Region – ZMR Blog
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Damage caused by Parkinson’s disease can be estimated via Waterlogged Brain Region

Damage caused by Parkinson’s disease can be estimated via Waterlogged Brain Region

Scientists are making constant research to get insights how diseases such as Parkinson’s develop. Another breakthrough in this field can be witnessed as a research team at the University of Florida hasrevealed a new technique of monitoring the brain changes resulted from Parkinson’s disease, which smashes neurons essential for movement. The progressionrecommends that fluid variations in a particular brain region candeliveranapproach to trace that damage.

Daofen Chen, NINDS Program Director, said,”By discovering a new approach to identify and trail how Parkinson’s damages the brain, this analysis offersa significant tool for evaluating whether a drug may stop or slow those variations and keep indications from getting worse.”

The team, led by David Vaillancourt, utilized a type of MRI that distinguishes between water enclosed in cells of brain and “free” water outside of cells. The study by the team concentrated on the substantia nigra, a structure within the brain where Parkinson’s disease destroys the neurons that utilize the chemical dopamine to interact with other cells. The outcomespresented that the free watervolume in that brain regionremainedunchanged over a year interval in healthy individuals, whereaselevated in early-stage Parkinson’s individuals during that duration and amplified further over the next 3 years.

 Parkinson's disease

This verifies and extends on anearlieranalysis by the same team that estimated free water over 1 year. The new results also showed the rise in free water was associatedwith worsening symptoms.The team utilized a scale to assess the movement issues of thepatient, from Stage 1 being the least severe to Stage 5 being the most advanced. Individuals who attain a stage up on the scale while the 4-yearstudy had a more free water risecompared toindividuals who persisted at the same stage, proposing the variationrevealed Parkinson’s-associatedharm to neurons.

Parkinson’s disease kills cells producing dopamine in the substantia nigra that connect to neighboring brain regions. The study by Dr. Vaillancourtexhibited that a higher free water rise in the substantia nigra was linkedto a drop in dopamine neuron activity in one of these adjacentareas, substantiating the notion that free water variations are associated with disease progression.

Dr. Vaillancourt said,”That connection is boosting as it pinpoints the biological significance of free water.” The results of the study propose that the MRI-based free water assessment can be utilized in Parkinson’s disease clinical studies. If a treatment stops or slows the rise in free water, it may be anindication that the drug is decelerating the progressive damage of dopamine neurons.

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