Cambridge Scientists Develop An Artificial Bile Duct For Transplantation – ZMR Blog
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Cambridge Scientists Develop An Artificial Bile Duct For Transplantation

Currently, there is almost no part left in the body that cannot be artificially produced.The increasing dysfunctionality of the vital body organs has encouraged the scientists to start growing the organs, for instance, the bile duct in an artificial environment. The scientists from the University of Cambridge have developed a new method for artificially forming the bile ducts in order to help treat the liver diseases in future rather than going for the liver transplantation procedure.


The scientists have been successful in creating a 3D cellular structure with the normal functionality.The normal functioning of the bile is important so as to secrete the bile enzymes that are necessary for carrying out the digestion process. Bile ducts are long tubular structures that if dysfunctional in a child can result in biliary atresia where the bile levels are fluctuating such that the liver is damaged.

For overcoming such diseases, the researchers have combined the tissue engineering technology and cell transplantation techniques to generate a transplant artificial bile duct of the humans. It can prove to be a future in the bile duct disease treatment. The scientists Professor Ludovic Vallier and Dr. Fotios Sampaziotis have taken healthy cholangiocytes from the bile duct and grown it till a 3D structure called the biliary organoids is developed. This organoid later formed a tubular structure similar to that of a natural bile duct.

Can a tubular structure be formed rather than the organoid? The scientists along with other researchers Mr. Alex Justin and Dr. Athina Markaki tried growing the biliary organoids on a biodegradable collagen scaffold so that a tube-like structure was formed, which could be directly used to replace damaged bile ducts. The scaffold helped the organoids form an artificial tube-like structure with normal bile duct functionality. This success was tested in the mice and proved to be a success.


The artificial human bile duct could help curb the bile duct disorder rate. The scientists aim using regenerative medicine and tissue engineering in order to generate bioengineered tissues for the bile diseases rather than relying on the transplantation process. This new therapeutic option can also help generate ducts for testing various drug effects in the near future.

Thus, the potential to find a cure for every disease in the near future is what the researchers are striving towards. Making the availability of healthy organs for the healthcare sector can help boost the life of people in the coming years.

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