Study Reveals Clot-Busting Drugs As Safe To Treat Patients With Dementia – ZMR Blog
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Study Reveals Clot-Busting Drugs As Safe To Treat Patients With Dementia

Study Reveals Clot-Busting Drugs As Safe To Treat Patients With Dementia

Stroke patients with dementia medicated with intravenous thrombolysis (IVT) using potent clot-busting medications are at no higher threat of death or brain hemorrhage than other individuals receiving the equal treatment. The most sort of stroke, ischemic stroke, results when a blood clot obstructs the flow of blood to the brain. Treating with IVT using potent clot-busting medications within 4.5 Hours of commencement can significantly enhance the prognosis and decrease the probability of patients losing the capability to walk or speak.

Sara Garcia-Ptacek from the Karolinska Institutet said, “Hospitals have been likely to draw back from giving potent clot-busting medications to individuals with dementia in the certainty that such patients, particularly those with Alzheimer’s, are more susceptible to brain hemorrhages. We sought to discover how immense this risk actually was.”

By analyzing information from the SveDem (Swedish Dementia Registry) between 2010 and 2014 & cross-indexing them with the Swedish Stroke Registry, the research team spotted 1,300 stroke patients with a prior diagnosis of some sort of dementia. Then they reviewed what percentage of the individuals had been given thrombolytic therapy for their stroke in comparison to a control group with stroke but without dementia. Through this, they discovered that individuals below 80 years with stroke and dementia were not given IVT as frequently as given to individuals with stroke but no dementia.


Therapeutic outcomes were examined for both the groups by researchers that were given thrombolysis treatment to determine whether or not the threat of complications differed. Maria Eriksdotter said, “It is imperative to emphasize that impulsive bleeding in the brain, referred as intra-cerebral hemorrhage, which is a recognized complication that can occur in combination with thrombolytic therapy, was no more likely in individuals with stroke and dementia than in non-demented individuals with stroke when both groups were given IVT.”

The research team also analyzed the peril of fatality after treatment and discovered that there was no disparity between individuals without and with dementia who received IVT. However, they did find the worse functional outcome in a patient with stroke and dementia 3 Months afterward. These individuals were also more prone to be dismissed to nursing homes contrast to stroke individuals without dementia.

Professor Eriksdotter said, “Our research designates that thrombolysis treatment is simply as harmless for patients with dementia as for other patients with the similar physical condition and that the threat of treatment impediments is no higher. Thus, IVT treatment can be deemed safe in stroke patients with dementia.”

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